Neurochemical changes in the pericalcarine cortex in congenital blindness attributable to bilateral anophthalmia

Neurochemical changes in the pericalcarine cortex in congenital blindness attributable to bilateral anophthalmia.

Congenital blindness leads to large-scale functional and structural reorganization in the occipital cortex, but relatively little is known about the neurochemical changes underlying this cross-modal plasticity. To investigate the effect of complete and early visual deafferentation on the concentration of metabolites in the pericalcarine cortex, (1)H magnetic resonance spectroscopy was performed...

Neurochemical changes in the pericalcarine cortex in congenital blindness 1 due to bilateral anophthalmia

Neurochemical changes in the pericalcarine cortex in congenital blindness 1 due to bilateral anophthalmia 2 Abbreviated title: Neurochemical changes in bilateral anophthalmia 3 4 Gaelle S L Coullon, Uzay Emir, Ione Fine, Kate E Watkins, Holly Bridge. 5 6 1 FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, 7 John Radcliffe Hospital, Oxford 8 2 Department of Psych...

A Case of Congenital Bilateral Anophthalmia

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Morphometric Changes of the Corpus Callosum in Congenital Blindness

We examined the effects of visual deprivation at birth on the development of the corpus callosum in a large group of congenitally blind individuals. We acquired high-resolution T1-weighted MRI scans in 28 congenitally blind and 28 normal sighted subjects matched for age and gender. There was no overall group effect of visual deprivation on the total surface area of the corpus callosum. However,...